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Description
CLEC9A Recombinant Rabbit mAb (S-1904-154)Product Specification Host Rabbit Antigen CLEC9A Synonyms C type lectin domain family 9 member A; CD370 Immunogen Synthetic Peptide Location Membrane Accession Q6UXN8 Clone Number S 1904 154 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage
Product Specification
| Host | Rabbit |
| Antigen | CLEC9A |
| Synonyms | C-type lectin domain family 9 member A; CD370 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q6UXN8 |
| Clone Number | S-1904-154 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | Hu |
| IF | 1:100 | Hu |
Background
CLEC9A (C-type lectin domain family 9 member A), also known as DNGR-1 (Dendritic Cell NK Lectin Group Receptor-1), is a type V C-type lectin-like receptor predominantly expressed on the surface of conventional dendritic cells (cDCs), specifically the CD8α+ subset in mice and CD141+ DCs in humans, as well as plasmacytoid dendritic cells (pDCs). This single-pass transmembrane protein features a C-terminal hemITAM-like signaling motif in its cytoplasmic tail, which enables SYK kinase recruitment and downstream signaling upon ligand engagement. CLEC9A functions as a specialized damage-associated molecular pattern (DAMP) receptor that recognizes filamentous actin (F-actin) exposed by necrotic cells but hidden in viable cells, thereby allowing dendritic cells to detect cell death and initiate immune responses. Upon binding to its ligand, CLEC9A triggers internalization of dead cell material into specialized endosomal compartments, facilitating efficient cross-presentation of necrotic cell-associated antigens to CD8+ T cells and thereby bridging innate recognition of cell injury with adaptive cytotoxic immunity. This unique capability makes CLEC9A crucial for anti-tumor immunity, viral clearance, and tissue homeostasis, while also serving as a promising therapeutic target for vaccine development and cancer immunotherapy through antibody-mediated targeting and adjuvant delivery systems.
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Exchange/Return Notes
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